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This paper reports the first release of the UMR (Uniform Meaning Representation) data set. UMR is a graph-based meaning representation formalism consisting of a sentence-level graph and a document-level graph. The sentence-level graph represents predicate-argument structures, named entities, word senses, aspectuality of events, as well as person and number information for entities. The document-level graph represents coreferential, temporal, and modal relations that go beyond sentence boundaries. UMR is designed to capture the commonalities and variations across languages and this is done through the use of a common set of abstract concepts, relations, and attributes as well as concrete concepts derived from words from invidual languages. This UMR release includes annotations for six languages (Arapaho, Chinese, English, Kukama, Navajo, Sanapana) that vary greatly in terms of their linguistic properties and resource availability. We also describe on-going efforts to enlarge this data set and extend it to other genres and modalities. We also briefly describe the available infrastructure (UMR annotation guidelines and tools) that others can use to create similar data sets. 

The axon initial segment (AIS) is a highly regulated subcellular domain required for neuronal firing. Changes in the AIS protein composition and distribution are a form of structural plasticity, which powerfully regulates neuronal activity and may underlie several neuropsychiatric and neurodegenerative disorders. Despite its physiological and pathophysiological relevance, the signaling pathways mediating AIS protein distribution are still poorly studied. Here, we used confocal imaging and whole-cell patch clamp electrophysiology in primary hippocampal neurons to study how AIS protein composition and neuronal firing varied in response to selected kinase inhibitors targeting the AKT/GSK3 pathway, which has previously been shown to phosphorylate AIS proteins. Image-based features representing the cellular pattern distribution of the voltage-gated Na+ (Nav) channel, ankyrin G, βIV spectrin, and the cell-adhesion molecule neurofascin were analyzed, revealing βIV spectrin as the most sensitive AIS protein to AKT/GSK3 pathway inhibition. Within this pathway, inhibition of AKT by triciribine has the greatest effect on βIV spectrin localization to the AIS and its subcellular distribution within neurons, a phenotype that Support Vector Machine classification was able to accurately distinguish from control. Treatment with triciribine also resulted in increased excitability in primary hippocampal neurons. Thus, perturbations to signaling mechanisms within the AKT pathway contribute to changes in βIV spectrin distribution and neuronal firing that may be associated with neuropsychiatric and neurodegenerative disorders.